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Searching for large genomic rearrangements of theBRCA1gene in a Nigerian population

✍ Scribed by Jing Zhang; James D. Fackenthal; Dezheng Huo; Yonglan Zheng; Olufunmilayo I. Olopade


Publisher
Springer US
Year
2010
Tongue
English
Weight
382 KB
Volume
124
Category
Article
ISSN
0167-6806

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## Abstract In most families with multiple cases of breast and ovarian cancer, the cancer appears to be associated with germline alterations in __BRCA1__ or __BRCA2__. However, somatic mutations in __BRCA1__ and __BRCA2__ in sporadic breast and ovarian tumors are rare, even though loss of heterozyg