Alcohol dependence is a leading cause of morbidity and premature death. Several lines of evidence suggest a substantial genetic component to the risk for alcoholism: sibs of alcoholic probands have a 3-8 fold increased risk of also developing alcoholism, and twin heritability estimates of 50-60% are
โฆ LIBER โฆ
Searching for genes affecting the structural integrity of the mitochondrial genome
โ Scribed by Massimo Zeviani; Patrizia Amati; Giacomo Comi; Giovanni Fratta; Caterina Mariotti; Valeria Tiranti
- Book ID
- 116159902
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 612 KB
- Volume
- 1271
- Category
- Article
- ISSN
- 0925-4439
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In the frame of the European Pilot Project for the functional analysis of newly discovered open reading frames (ORFs) from Sacchavomyces cerevisiae chromosome 111, we have deleted entirely the YCR46C ORF by a one-step polymerase chain reaction method and replaced it by the HIS3 marker in the strain