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Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

✍ Scribed by Griffin, Roger J.; Henderson, Andrew; Curtin, Nicola J.; Echalier, Aude; Endicott, Jane A.; Hardcastle, Ian R.; Newell, David R.; Noble, Martin E. M.; Wang, Lan-Zhen; Golding, Bernard T.

Book ID: 121223512
Publisher: American Chemical Society
Year: 2006
Tongue: English
Weight: 98 KB
Volume: 128
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja060595j

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## Abstract Granulosa cell tumors (GCTs) of the ovary are relatively rare and account for <5% of all ovarian cancers. The molecular pathogenesis of these tumors is not well understood. We tested the hypothesis that cyclin‐dependent kinase inhibitors, specifically the __in__hibitors of the cyclin‐de