The frustrating search for schizophrenia
โ Tsuang, Ming T.; Paraone, Stephen V.
๐ Article
๐
2000
๐ John Wiley and Sons
๐ English
โ 7 KB
โฆ LIBER โฆ
Searching for a locus for schizophrenia within chromosome Xp11
โ Scribed by Wei, J.; Hemmings, G.P.
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 16 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0148-7299
- DOI
- 10.1002/(sici)1096-8628(20000207)96:1<4::aid-ajmg2>3.0.co;2-z
No coin nor oath required. For personal study only.
โฆ Synopsis
Three gene-rich loci-HS212G6, HSU93305, and HS884M20-within the short arm of the X chromosome have been examined for allelic association with schizophrenia by the transmission disequilibrium test in 70 families of male individuals affected with schizop h r e n i a . N e i t h e r t h e H S 2 1 2 G 6 n o r HS884M20 was found to be associated with schizophrenia. The HSU93305 locus, however, was significantly associated with schizophrenia (X 2 =17.92, df=3, P<0.001). The HSU93305 locus contains four distinct genes. They code, respectively, for A4 differentiation-dependent protein, triple LIM domain protein, synaptophysin, and calcium channel alpha-1 subunit. It is possible that one of these genes or some loci near to it may predispose a vulnerability to schizophrenia.
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## Recent reports on potential linkage by Faraone and the NIMH Genetics Initiative-Millennium Schizophrenia Consortium [1997: Am J Med Genet 74:557], and by Straub et al. [1997: Am J Med Genet 74:558], prompted us to study chromosome 10 in a sample of 72 families containing 2 or more affected sibs