Search for nonallelic structural genes for γ-chains of fetal hemoglobin in some primates

✍ Scribed by T. H. J. Huisman; W. A. Schroeder; M. E. Keeling; N. Gengozian; A. Miller; A. R. Brodie; J. R. Shelton; J. B. Shelton; G. Apell

• Publisher: Springer
• Year: 1973
• Tongue: English
• Weight: 458 KB
• Volume: 10
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00485708

✦ Synopsis

Peptide yCB-3 is the indicator of the presence and activity of nonallelie structural genes for the human y-chain. An equivalent peptide has been isolated from the HbF of the marmoset (Saguinus fuscicollis), the rhesus monkey (Macaca mulatta), the orangutan (Pongo pygmaeus), and the gorilla (Gorilla gorilla gorilla). The sequence of 7CB-3 from the marmoset and the rhesus monkey, although different from that of human yCB-3, gives no evidence of heterogeneity of the HbF. However, the HbF of the rhesus monkey is itself heterogeneous, and there probably is a difference in another part of the y-chain. The 7CB-3 peptide of the orangutan is definitely heterogeneous: the heterogeneity is in position 135, however, rather than in position 136 as in human 7CB-3. The gorilla has the same type of heterogeneity at position 136 as does the human, but the proportions of the two types of chains might differ in the two species.