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Search for a Susceptibility Locus to Tardive Dyskinesia

✍ Scribed by TOSHIYA INADA; IZUMI DOBASHI; TETSUYOSHI SUGITA; ATARU INAGAKI; YOSHIE KITAO; GENICHI MATSUDA; SHINGO KATO; TOSHIYA TAKANO; GOHEI YAGI; MASAHIRO ASAI

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 83 KB
Volume: 12
Category: Article
ISSN: 0885-6222
DOI: 10.1002/(sici)1099-1077(199701/02)12:1<35::aid-hup828>3.0.co;2-#

No coin nor oath required. For personal study only.

✦ Synopsis

In order to ®nd a genetic marker for vulnerability to tardive dyskinesia (TD), we looked for an association between vulnerability to TD and polymorphic sites in the gene loci encoding the dopamine D2 receptor (Nco I site), the dopamine D3 receptor (Bal I site), and the dopamine transporter (40-bp, tandem repeat polymorphism). No signi®cant dierence was observed in the allele and genotype frequencies of any of the polymorphic sites examined, when comparing psychiatric patients who were speci®cally vulnerable to TD (n 49) and those who were not (n 56). These results suggest that the polymorphic gene loci examined in the present study are unlikely to be of major aetiologic importance in the development of TD.

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