Scutellaria baicalensis, a herbal medicine: Anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines
✍ Scribed by Takashi Kumagai; Claudia I. Müller; Julian C. Desmond; Yasufumi Imai; David Heber; H. Phillip Koeffler
- Book ID
- 104040262
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 604 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0145-2126
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✦ Synopsis
Scutellaria baicalensis (S.B.) is a widely used Chinese herbal medicine. We initially investigated its in vitro anti-tumor activities. S.B inhibited the growth of ALL, lymphoma and myeloma cell lines by inducing apoptosis and cell cycle arrest at clinically achievable concentrations. The anti-proliferative effect was associated with mitochondrial damage, modulation of the Bcl family of genes, increased level of the CDK inhibitor p27 KIP1 and decreased level of c-myc oncogene. HPLC analysis of S.B. showed it contains 21% baicalin and further studies confirmed it was the major anti-cancer component of S.B. Thus, Scutellaria baicalensis should be tested in clinical trials for these hematopoietic malignancies.