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Screening of Patients with Multiple Endocrine Neoplasia Type 1 (MEN-1): A Critical Analysis of Its Value

✍ Scribed by Jens Waldmann; Volker Fendrich; Nils Habbe; Detlef K. Bartsch; Emily P. Slater; Peter H. Kann; Matthias Rothmund; Peter Langer

Publisher
Springer
Year
2009
Tongue
English
Weight
267 KB
Volume
33
Category
Article
ISSN
0364-2313

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Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by tumors in parathyroids, enteropancreatic endocrine tissues, anterior pituitary, and other tissues. The gene for MEN1 has recently been cloned and shown to code for a 610-amino acid protein of enigmatic func

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The gene responsible for multiple endocrine neoplasia type I (MEN-l) syndrome has been mapped to chromosome l lq13. It appears to function as a tumoursuppressor gene analogous to that for retinoblastoma and allelic losses involving the wild-type of the MEN-1 allele have been found in parathyroid and

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