Screening method for the evaluation of asymmetric catalysts for the reduction of aliphatic ketones

✍ Scribed by Mourad Boukachabia; Saoussen Zeror; Jacqueline Collin; Jean-Claude Fiaud; Louisa Aribi Zouioueche

• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 376 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2011.01.112

✦ Synopsis

ATH reductions of aliphatic ketones in water catalyzed by ruthenium coordinated by prolinamide ligands produce alcohols with moderate enantiomeric excesses in most cases. A set of seven aliphatic ketones is proposed for a rapid evaluation of the enantioselectivity of catalysts by one-pot multi-substrates reduction. The screening of a library of prolinamides shows that according to the structure of the ketones different ligands give the best asymmetric inductions.