✦ LIBER ✦

Screening method for PAF antagonist substances: on the phenolic compounds from Impatients balsamina L.

✍ Scribed by Hisae Oku; Kyoko Ishiguro

Book ID: 101290950
Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 91 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199909)13:6<521::aid-ptr535>3.0.co;2-a

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✦ Synopsis

A blood pressure monitoring system was developed for studying antagonist effects against platelet activating factor (PAF), a chemical mediator of anaphylactic hypotension. Using this system, we were able to determine the inhibitory effects of a 35% ethanol extract (IB) from the petals of Impatiens balsamina L. against PAF-induced hypotension and the active principal compounds from IB. One mechanism of the antianaphylactic effects of IB was characterized as PAF-antagonist effects.