Screening forBRCA1,BRCA2,CHEK2, PALB2,BRIP1,RAD50, andCDH1mutations in high-risk FinnishBRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals
β Scribed by Kirsi M Kuusisto; Aleksandra Bebel; Mauno Vihinen; Johanna Schleutker; Satu-Leena Sallinen
- Book ID
- 118726733
- Publisher
- BioMed Central
- Year
- 2011
- Tongue
- English
- Weight
- 549 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr2832
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Germline mutations in the BRCA1 and BRCA2 genes account for the majority of high-risk breast/ovarian cancer families, depending on the population studied. Previously, BRCA1 mutations were described in women from Western Poland. To further characterize the spectrum of BRCA1 mutations and the impact o
Two potential breast cancer susceptibility genes, encoding the BRCA1-interacting proteins ZNF350 (or ZBRK1) and BRIP1 (or BACH1), have been identified in yeast two-hybrid screens. We sequenced these genes in probands from 21 families with potentially inherited breast/ovarian cancer, all of which wer