Screening for LRRK2 mutations in patients with Parkinson’s disease in Russia: identification of a novel LRRK2 variant
✍ Scribed by S. N. Pchelina; A. F. Yakimovskii; A. K. Emelyanov; O. N. Ivanova; A. L. Schwarzman; A. B. Singleton
- Book ID
- 111065502
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 164 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1351-5101
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## Abstract Mutations in the leucine‐rich repeat kinase 2 (__LRRK2__) gene are the most common genetic determinant of Parkinson's disease (PD) in European‐derived populations, but far less is known about __LRRK2__ mutations and susceptibility alleles in Asians. To address this issue, we sequenced t
## Abstract To investigate the frequency of mutations in the Leucine‐Rich Repeat Kinase 2 gene (__LRRK2__) in a sample of Austrian Parkinson's disease (PD) patients, we sequenced the complete coding region in 16 patients with autosomal dominant PD. Furthermore, we sequenced exons 31, 35, and 41 add