Screening for Inclusion Compounds and Systematic Construction of Three-Component Solids by Liquid-Assisted Grinding

✍ Scribed by Tomislav Friščić; Andrew V. Trask; William Jones; W. D. Samuel Motherwell

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 297 KB
• Volume: 118
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.200603235

✦ Synopsis

The rational construction of cocrystals (crystalline solids made up of more than one molecular component) has recently attracted the attention of solid-state scientists and materials chemists. [1] The interest, founded on the growing number of applications of multicomponent solids, includes the discovery of new cocrystals, as well as the development of efficient methods for cocrystal synthesis and screening. [2,3] Whereas reliable strategies have been developed to design and construct two-component (binary) cocrystals by using hydrogen bonds, [4] halogen bonds, [5] p•••p [6] or van der Waals forces, [7] the construction of ternary and higher-order cocrystals still presents a challenge.