Screening and Clinical Implications for BRCA1 and BRCA2 Mutation Carriers
β Scribed by Sharon E. Plon
- Book ID
- 110375633
- Publisher
- Springer US
- Year
- 1998
- Tongue
- English
- Weight
- 191 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1083-3021
No coin nor oath required. For personal study only.
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## Abstract There is conflicting evidence as to whether individuals who are heterozygous for germβline __BRCA1__ or __BRCA2__ mutations have an altered phenotypic cellular response to irradiation. To investigate this, chromosome breakage and apoptotic response were measured after irradiation in per
The identification of cancer susceptibility genes offers new avenues for selecting high-risk individuals as subjects for chemoprevention trials. Because carriers of predisposing mutations are at high risk, they are more likely to enroll and comply with chemoprevention trials, and meaningful results