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Screening a 2 cM genetic map for allelic association: A simulated oligogenic trait

✍ Scribed by Dr. David L. Duffy

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 294 KB
Volume: 12
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370120612

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✦ Synopsis

In this paper, we explore the use of a variety of familial transmission tests (and case-control analyses) to screen for allelic associations in simulated marker data of a quality (2 cM map) that will feasibly arise from genomic scans within the next 5-10 years. We demonstrate a form of the transmission-disequilibrium test extended to multiallele systems. The methods used were log-linear and related models implemented largely using standard statistical packages.

1995 Wiley-Liss, Inc.

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