SCREAMING BONES by Pat Burden

Screaming Bones

✍ Burden, Pat 📂 Fiction 📅 0 🌐 English ⚖ 119 KB

Skeletal metastases: Decreasing tumor bu

Skeletal metastases: Decreasing tumor burden by targeting the bone microenvironment

✍ John M. Chirgwin; Theresa A. Guise 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 162 KB

## Abstract Several common cancers often metastasize to the skeleton in advanced disease. Bone metastases are incurable and cause protracted, severe symptoms. Growth of tumor in bone is driven by a vicious cycle: tumor‐secreted factors stimulate bone cells, which in turn release growth factors and