𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Scrambled or bisected mouse eggs and the basis of patterning in mammals

✍ Scribed by Richard L. Gardner

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
58 KB
Volume
21
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

Several findings challenge the notion that specification of cell types and embryonic axes in mammals are rooted entirely in the temporal and spatial relations between cleaving blastomeres. They raise the question as to whether, as in most non-mammalian species, these processes depend on information already present in the egg. However, experiments designed to investigate this possibility directly by perturbing the organization of the zygote or, very recently, by deleting one or other of its polar regions [M. Zernicka-Goetz. Fertile offspring derived from mammalian eggs lacking either animal or vegetal poles. Development 1998;125:4803-4808 (Ref. 1)], have been interpreted to mean that such a role for the egg can be discounted. This conclusion seems premature in view of continuing uncertainty regarding the developmental potential of individual blastomeres in mammals.

📜 SIMILAR VOLUMES

Penetration of the zona-free or intact e
Penetration of the zona-free or intact eggs by foreign spermatozoa and the fertilization of deer mouse eggs in vitro
✍ Hanada, A. ;Chang, M. C. 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 788 KB

## Abstract Zona‐free eggs were introduced to fresh or preincubated sperm suspensions and the penetration of eggs by foreign spermatozoa was examined, as evidenced by enlargement of the sperm head and formation of the male pronucleus. It was found that zona‐free hamster eggs can be penetrated by gu

Release of mouse eggs from metaphase arr
Release of mouse eggs from metaphase arrest by protein synthesis inhibition in the absence of a calcium signal or microtubule assembly
✍ Dr. Ruth M. Moses; Douglas Kline 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 914 KB

## Abstract Mouse egg activation, which includes release from meiotic metaphase II arrest, results from fertilization‐induced increase in intracellular calcium concentration ([Ca^2+^]~i~). However, during egg activation caused by exposure to the protein synthesis inhibitor, cycloheximide, [Ca^2+^]~