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Scoring systems in mantle cell lymphoma: A critical point of view

✍ Scribed by Jordi Juncà; Neus Ruiz-Xivillé; Isabel Granada; Inés Rodríguez-Hernández; Josep-Tomàs Navarro; José Luis Mate; Fuensanta Millá

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
712 KB
Volume
82B
Category
Article
ISSN
1552-4949

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✦ Synopsis

Abstract

A proposal for a scoring system in the diagnosis of chronic lymphoproliferative diseases other than CLL has been recently published in Cytometry Part B. The authors apply this score for deciding whether or not FISH evaluation for the detection of IGH/CCND1 rearrangements must be performed to exclude Mantle Cell Lymphoma (MCL). In their validation series, no MCL scored <3. We have applied their system to our cases of MCL and also to a small series of Marginal Zone lymphomas. In our hands, the scoring system as has been published does not discriminate adequately between both entities. We propose using the negativity of a marker, CD11c, instead of the platelet count to improve the results. However, we believe that given the clinical and prognostic implications of the diagnosis of MCL, scoring systems should be greatly ameliorated prior to their generalized use. © 2011 International Clinical Cytometry Society

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