Scopadulcic acid-A and -B, new diterpenoids with a novel skeleton, from a Paraguayan crude drug “typychá kuratũ” (scoparia dulcis L.)

✍ Scribed by Toshimitsu Hayashi; Mieko Kishi; Masaru Kawasaki; Munehisa Arisawa; Mineo Shimizu; Shoichi Suzuki; Masao Yoshizaki; Naokata Morita; Yasuhiro Tezuka; Tohru Kikuchi; Luis H. Berganza; Esteban Ferro; Isabel Basualdo

• Book ID: 104227763
• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 274 KB
• Volume: 28
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)96357-3

✦ Synopsis

Scopadulcic acid-A and -B, diterpenoids with a novel skeleton, have been isolated from the whole plants of Scoparia dulcis L., and their structures, including the absolute configuration, were determined based on the Z-D NMR and CD spectral data. During our investigation on biologically active substances from Paraguayan medicinal plants, a new labdane-type diterpenoid, scoparic acid-A (l), was isolated from the 70% ethanol extract of "Typychs kuratii" (whole plants of Scoparia dulcis L., Scrophuraliaceae). 1) From the same source, we have now isolated two novel diterpenoids, named scopadulcic acid-A (2) and -B (3). In this communication, structures of scopadulcic acid-A and -B, including their absolute stereochemistry, are described. Scopadulcic acid-A (2), colorless prisms (MeOH), mp 172-174", [(w]E7-5.7" (MeOH), has the molecular formula C27H3406 (M+ 454.2313, calcd. 454.2354) and its UV and IR spectra showed