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SCLEROSTIN NEUTRALIZING ANTIBODY ENHANCES BONE HEALING DURING DISTRACTION OSTEOGENESIS IN RATS

✍ Scribed by Michelle McDonald; Lauren Peacock; Kathy Mikulec; Oliver Birke; Min Liu; Scott Wasserman; Hua Zhu “David” Ke; David Little

Book ID
117981703
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
58 KB
Volume
46
Category
Article
ISSN
8756-3282

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## Abstract Sclerostin is the product of the __SOST__ gene. Loss‐of‐function mutations in the __SOST__ gene result in a high‐bone‐mass phenotype, demonstrating that sclerostin is a negative regulator of bone mass. Primarily expressed by osteocytes in bone, sclerostin is reported to bind the LRP5/6