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Sclerostin monoclonal antibody therapy with AMG 785: a potential treatment for osteoporosis

โœ Scribed by Lewiecki, E Michael

Book ID
125510590
Publisher
Informa plc
Year
2010
Tongue
English
Weight
232 KB
Volume
11
Category
Article
ISSN
5847-4714

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โœ Desmond Padhi; Graham Jang; Brian Stouch; Liang Fang; Edward Posvar ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› American Society for Bone and Mineral Research ๐ŸŒ English โš– 248 KB

Sclerostin, an osteocyte-secreted protein, negatively regulates osteoblasts and inhibits bone formation. In this first-in-human study, a sclerostin monoclonal antibody (AMG 785) was administered to healthy men and postmenopausal women. In this phase I, randomized, double-blind, placebo-controlled, a