Scleromyxedema revisited

✍ Scribed by John J. Pomann; Earl J. Rudner

• Book ID: 104463868
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 217 KB
• Volume: 42
• Category: Article
• ISSN: 0011-9059
• DOI: 10.1046/j.1365-4362.2003.01565.x

✦ Synopsis

Abstract

Scleromyxedema is a rare disease characterized by papular mucinous deposits, dermal fibroblast proliferation, and a monoclonal paraproteinemia. Its chronic course tends to be complicated by gastrointestinal, muscular, pulmonary, and neurologic disorders. We review the literature to identify the common systemic manifestations and suggest a clinical approach to this disorder. This should include: identification of the characteristic lesions, a skin biopsy, and serum protein electrophoresis. A thyroid evaluation may help differentiate this condition from others. An early neurologic, gastrointestinal, and cardiovascular evaluation should be considered.