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Scleroderma is associated with differences in individual routes of drug metabolism: A study with dapsone, debrisoquin, and mephenytoin

โœ Scribed by May, D Gail; Black, Carol M; Olsen, Nancy J; Csuka, Mary E; Tanner, S Bobo; Bellino, Lisa; Porter, James A; Wilkinson, Grant R; Branch, Robert A


Book ID
109844769
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
753 KB
Volume
48
Category
Article
ISSN
0009-9236

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## Abstract Malignant activation of oncogenes __ras__ or __trk__ is implicated in a number of solid tumors and leukemias. We determined the chemosensitivity profile of wildโ€type mouse NIHโ€3T3 fibroโ€blasts, and that of NIHโ€3T3 lines transformed by the Hโ€__ras__ (S2โ€721) and __trk__ (106โ€“632) oncogen