Scleroderma, fibroblasts, signaling, and excessive extracellular matrix
β Scribed by Hironobu Ihn
- Book ID
- 107553813
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 182 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1523-3774
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π SIMILAR VOLUMES
TGF-b is the primary inducer of extracellular matrix proteins in scleroderma (systemic sclerosis, SSc). Previous studies indicate that in a subset of SSc fibroblasts TGF-b signaling is activated via elevated levels of activin receptor-like kinase (ALK) 1 and phosphorylated Smad1 (pSmad1). The goal o
## Abstract ## Objective As an initial approach to understanding the basis of the systemic sclerosis (SSc; scleroderma) phenotype, we sought to identify genes in the transforming growth factor Ξ² (TGFΞ²) signaling pathway that are upβregulated in lesional SSc fibroblasts relative to their normal cou
Cells contracting connective tissue matrices generate tractional forces in tissues. Studies of fibroblast contraction, using collagen gels in an in vitro model, demonstrate that it involves the actin cytoskeleton, specific extracellular matrix receptors and requires stimulation by exogenous promoter