## Abstract The role of colony stimulating factor‐1 (CSF‐1) in the regulation of osteoclasts and bone remodeling suggests that CSF‐1 may also be involved in regulation of bone healing. The ability of CSF‐1 to promote healing of bone defects was tested in a rabbit model. Twenty‐four New Zeeland rabb
Scintigraphic control of bone-fracture healing under ultrasonic stimulation: An animal experimental study
✍ Scribed by Winfried Klug; Wolf-Gunter Franke; Hans-Georg Knoch
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 954 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0340-6997
No coin nor oath required. For personal study only.
✦ Synopsis
In a model of closed lower-leg fracture in rabbits and of secondary bone-fracture healing, scintigraphic control until biological healing was performed. Biological fracture healing was assumed for a region of interest (ROI)-activity ratio close to 1.0. After application of 99mTc-HEDP, 151 examinations were performed. ROI activity increased significantly until day 14 p.i. and reached the maximum value (Q = 6.44) on day 14 postfracture. Sixty-one lower leg fractures were treated by ultrasound from days 14-28 postfracture. These stimulated fractures were biologically healed on day 168 postfracture. The fractures that were not treated by ultrasound could not be detected by scanning after day 203 postfracture.
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