Schizophrenia and chromosome 6p

✍ Scribed by Turecki, Gustavo; Rouleau, Guy A.; Joober, Ridha; Mari, Jair; Morgan, Kenneth

• Book ID: 101216707
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 97 KB
• Volume: 74
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/(sici)1096-8628(19970418)74:2<195::aid-ajmg16>3.0.co;2-d

✦ Synopsis

Several studies have recently reported genetic linkage between markers located on the short arm of chromosome 6 and schizophrenia. Valid conclusions, however, are difficult to formulate because chromosomal markers that yielded positive results span a relatively large region of chromosome 6, and studies did not necessarily obtain consistent results with regard to the particular loci tested. Here, we report a meta-analysis of the results of linkage studies of schizophrenia that used chromosome 6p markers. After conducting a systematic search, nine different studies were selected for the analysis using defined criteria. Pooled P values were obtained for all common markers investigated and provided additional support for a major susceptibility locus for schizophrenia in this region. In addition, two markers located 2 cM apart, D6S274 and D6S285, provided the most significant results. These findings may help narrow the chromosomal region in the search for a major gene implicated in schizophrenia. Am.