Schilancidilactones A and B: two novel tetranortriterpenoids with an unprecedented skeleton from Schisandra lancifolia

✍ Scribed by Xiao Luo; Ying Chang; Xing-Jie Zhang; Jian-Xin Pu; Xue-Mei Gao; Ying-Li Wu; Rui-Rui Wang; Wei-Lie Xiao; Yong-Tang Zheng; Yang Lu; Guo-Qiang Chen; Qi-Tai Zheng; Han-Dong Sun

• Book ID: 104096879
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 303 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.08.051

✦ Synopsis

Schilancidilactones A (1) and B (2), two novel tetranortriterpenoids possessing an unprecedented skeleton, have been isolated from the stems of Schisandra lancifolia. Their structures were elucidated on the basis of extensive spectroscopic analysis. The relative configurations of 1 were further determined by single-crystal X-ray crystallography. Compounds 1 and 2 were tested for their cytotoxicity against four tumor cell lines NB4, A549, SH-SY5Y, and PC-3, and compound 1 was further tested for its anti-HIV-1 activity.