SCCA-IgM is predictive of hepatocellular carcinoma development in patients with HCV cirrhosis—A prospective study
✍ Scribed by Biasiolo, A.; Trotta, E.; Fasolato, S.; Tono, N.; Ruvoletto, M.G.; Martini, A.; Terrin, L.; Fassina, G.; Angeli, P.; Gatta, A.; Pontisso, P.
- Book ID
- 122168844
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 59 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1590-8658
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## Abstract About 3–4% of cirrhotic patients develop primary liver cancer every year. Specific serologic markers have not yet been identified for screening of high risk patients. The serpin squamous cell carcinoma antigen (SCCA) is overexpressed in liver cancer and circulating SCCA‐IgM complexes ha
W e prospectively monitored 140 cirrhotic patients for the development of hepatocellular carcinoma for 6 yr, using periodical screening by high-resolution convex-array ultrasonography and a-fetoprotein. Twenty-eight patients were positive for HBs antigen, 26 patients had received blood transfusions