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SCC-S2 is overexpressed in colon cancers and regulates cell proliferation

โœ Scribed by Miao, Zhifeng; Zhao, Tingting; Wang, Zhenning; Xu, Yingying; Song, Yongxi; Wu, Jianhua; Xu, Huimian

Book ID
118302837
Publisher
S. Karger AG
Year
2012
Tongue
English
Weight
540 KB
Volume
33
Category
Article
ISSN
1010-4283

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## Abstract JMJD2A is a transcriptional cofactor and enzyme that catalyzes demethylation of histone H3 lysines 9 and 36 and is overexpressed in human tumors, but its role in oncogenesis remains unclear. Here, we show that JMJD2A interacts with the tumor suppressor p53 both in vitro and in HCT116 co