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Scanning electron microscopy of differentiated liver cells transformed in vitro by chemical carcinogens

✍ Scribed by Borek, Carmia

Publisher
Wiley (John Wiley & Sons)
Year
1979
Tongue
English
Weight
438 KB
Volume
12
Category
Article
ISSN
0091-7419

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✦ Synopsis

A scanning electron microscopy study was carried out on differentiated liver cells transformed in vitro by three chemical carcinogens into cells that give rise t o carcinomas. The results indicate that the transformed cells grow as a rule in tightly adherent monolayers but differ in topography. There is a tendency toward heterogeneity in cell shape compared to the normal and on the whole toward a larger number of surface microvilli in the malignant cell population. However, both in sparse and confluent cultures the topographic differences are often not striking enough t o unequivocally distinguish single neoplastic cells from the normal.

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