Scandium trisdodecylsulfate (STDS). A new type of lewis acid that forms stable dispersion systems with organic substrates in water and accelerates aldol reactions much faster in water than in organic solvents

✍ Scribed by Shū Kobayashi; Takeshi Wakabayashi

• Book ID: 104259560
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 297 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01081-8

✦ Synopsis

A new type of Lewis acid, scandium trisdodecylsulfate (STDS), was prepared. In the presence of a catalytic amount of STDS, aldol reactions of silyl enol ethers with aldehydes proceeded smoothly in water without using any organic solvents. It was proven that stable dispersion systems including the catalyst and organic substrates were formed in water and that catalytic activity in water was much higher than that in organic solvents. As far as we know, this is the first example of Lewis acid catalysis in stable dispersion system in water.