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Scaling the Druggability Landscape of Human Bromodomains, a New Class of Drug Targets

✍ Scribed by Zhang, Guangtao; Sanchez, Roberto; Zhou, Ming-Ming

Book ID
115509881
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
176 KB
Volume
55
Category
Article
ISSN
0022-2623

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## Abstract Carbonic anhydrases (CAs, EC 4.2.1.1) are a family of enzymes widespread in all life kingdoms. In mammals, isozyme CA IX is highly overexpressed in many cancer types being present in few normal tissues. Its expression is strongly induced by hypoxia present in many tumors, being regulate