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Scale-Up Synthesis of the Dopamine Uptake Inhibitor GBR-12909

✍ Scribed by Ironside, Michael D.; Sugathapala, Priyantha M.; Robertson, Jerod; Darey, Mark C. P.; Zhang, Jianzhong

Book ID
118019326
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
144 KB
Volume
6
Category
Article
ISSN
1083-6160

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Synthesis of [18F]GBR 12909, a dopamine
Synthesis of [18F]GBR 12909, a dopamine reuptake inhibitor
✍ Michael S. Haka; Michael R. Kilbourn πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 French βš– 304 KB πŸ‘ 1 views

## Abstract Preparation of no‐carrier‐added fluorine‐18 labeled GBR 12909 (1‐[2‐(bis(4‐fluorophenyl)methoxy)ethyl]‐4‐(3‐phenylpropyl)piperazine), a specific and high affinity inhibitor of dopamine reuptake, is described. 4‐Fluoro‐4′‐[^18^F]fluorobenzophenone was prepared by [^18^F]fluoride ion subs