We have studied a thermolysin-catalyzed solidto-solid dipeptide synthesis using equimolar amounts of Z-Gln-OH and H-Leu-NH 2 as model substrates. The high substrate concentrations make this an effective alternative to enzymatic peptide synthesis in organic solvents. Water content was varied in the r
Scale-up of enzymatic solid-to-solid peptide synthesis and enzyme recovery
β Scribed by Markus Erbeldinger; Peter J. Halling; Xiongwei Ni
- Publisher
- American Institute of Chemical Engineers
- Year
- 2001
- Tongue
- English
- Weight
- 922 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0001-1541
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A systematic study of thermolysin-catalyzed solid-to-solid peptide synthesis using Z-Gln and Leu-NH 2 as model substrates was carried out. The aim was to extend the kinetic knowledge of this new reaction system involving highly concentrated substrate mixtures with little water (10% to 20% w/w). Preh
## Abstract The successful scaleβup of the enzymatic synthesis of Ξ±βmethyl glucoside acrylate from laboratoryβscale (milliliter) to pilotβscale (liter) was examined. Specifically, __Candida antarctica__ lipase B (Novozym 435) was used as a biocatalyst to produce Ξ±βmethyl glucoside acrylate via the
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v