✦ LIBER ✦
Scale-up of analytical chromatography to the simulated moving bed separation of the enantiomers of the flavour norterpenoids α-ionone and α-damascone
✍ Scribed by Gianmarco Zenoni; Francesca Quattrini; Marco Mazzotti; Claudio Fuganti; Massimo Morbidelli
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 137 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0882-5734
- DOI
- 10.1002/ffj.1088
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✦ Synopsis
Abstract
The scale‐up of the HPLC separation of the enantiomers of the flavour norterpenoid ketones α‐ionone and α‐damascone from analytical to preparative scale was achieved using the chromatographic simulated moving bed (SMB) technique. Commercial HPLC columns, with heptakis‐(2,3,6‐per‐O‐methyl)‐β‐cyclodextrin bound to silica gel as chiral stationary phase, were employed for the separation. High‐purity enantiomers of both chiral compounds have been obtained with a rather satisfactory productivity. Copyright © 2002 John Wiley & Sons, Ltd.