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Scabronines B, C, D, E and F, novel diterpenoids showing stimulating activity of nerve growth factor-synthesis, from the mushroom Sarcodon scabrosus

โœ Scribed by Takako Kita; Yoshiaki Takaya; Yoshiteru Oshima; Tomihisa Ohta; Koichi Aizawa; Takaaki Hirano; Takahiro Inakuma

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
654 KB
Volume
54
Category
Article
ISSN
0040-4020

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โœฆ Synopsis

Novel cyathane-type diterpenoids, scabronines B -F (1 -5) were isolated from the mushroomSarcodonscabrosus. Their structures were determined by interpretation of their spectral data and chemical transformation. The absolute stereochemistry of scabronine C (2) was confirmed by the exciton chirality method, and the chemical transformation of scabrenines B, C and D (1, 2 and 3) clarified their absolute structures. The absolute stereochemistries of scabronines E and F (4 and S) were determined by comparison of their CD spectra with that of erinacine A (7). Among these compounds, scabrenines B, C and E (1, 2 and 4) exhibit stimulating activity of the synthesis of a nerve growth factor.

๐Ÿ“œ SIMILAR VOLUMES

Scabronine A, a novel diterpenoid having
Scabronine A, a novel diterpenoid having potent inductive activity of the nerve growth factor synthesis, isolated from the mushroom, Sarcodon scabrosus
โœ Tomihisa Ohta; Takako Kita; Norihiro Kobayashi; Yutaro Obara; Norimichi Nakahata ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 213 KB

A novel diterpenoid, scabronine A, having strong inductive activity of the nerve growth factor synthesis was isolated from the fruit body of the mushroom, Sareodon scabrosus (Fr.) Karst. The stereostructure of scabronine A (1) was elucidated on the basis of the spectroscopic analysis of natural sca