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SC35 Plays a Role in T Cell Development and Alternative Splicing of CD45

✍ Scribed by Huan-You Wang; Xiangdong Xu; Jian-Hua Ding; John R Bermingham Jr.; Xiang-Dong Fu


Book ID
117736475
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
905 KB
Volume
7
Category
Article
ISSN
1097-2765

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CD4, CD8 and the role of CD45 in T-cell
✍ Jeffrey A. Ledbetter; Julie P. Deans; Alejandro Aruffo; Laura S. Grosmaire; Stev πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 1009 KB

CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta