𝔖 Bobbio Scriptorium
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SAXS study of the snake toxin α-crotamine

✍ Scribed by J. R. Beltran; Y. P. Mascarenhas; A. F. Craievich; C. J. Laure

Publisher
Springer
Year
1990
Tongue
English
Weight
401 KB
Volume
17
Category
Article
ISSN
1432-1017

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✦ Synopsis

alpha-crotamine is a small toxic protein (42 amino acid residues with three disulphide bridges) present in the venom of Crotallus durissus terrificus. Molecular parameters (Rg = 13.7 A, S = 3,000 A2, V = 9,200 A3 and Dmax = 40 A) were derived from SAXS curves obtained from a solution of this protein at pH = 4.5. An excellent agreement between the experimental distance distribution curve and that calculated from a model consisting of two lobes linked by the Cys(18)-Cys(30) disulphide bridge.

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