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Saturable Tissue Binding and Imirestat Pharmacokinetics in Rats

โœ Scribed by Jenny Y. Chien; Christopher R. Banfield; Romulus K. Brazzell; Philip R. Mayer; John T. Slattery

Book ID
110343220
Publisher
Springer US
Year
1992
Tongue
English
Weight
823 KB
Volume
09
Category
Article
ISSN
0724-8741

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โœ Bela A. Patel; Chung K. Chu; F. Douglas Boudinot ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 671 KB

The purpose of this study was to assess the effects of dose on the pharmacokinetics of zidovudine (3'-azido-3'-deoxythymidine; AZT) in rats. Zidovudine (AZT) was administered intravenously at doses of 10, 50, 100, and 250 mgikg. Plasma and urine AZT concentrations were determined by HPLC. Plasma AZT