✦ LIBER ✦

SAR studies of acidic dual γ-secretase/PPARγ modulators

✍ Scribed by Martina Hieke; Julia Ness; Ramona Steri; Christine Greiner; Oliver Werz; Manfred Schubert-Zsilavecz; Sascha Weggen; Heiko Zettl

Book ID: 113495413
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 908 KB
Volume: 19
Category: Article
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2011.08.003

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Quinoline-Based Derivatives of Pirinixic

Quinoline-Based Derivatives of Pirinixic Acid as Dual PPAR α/γ Agonists.

✍ Laura Popescu; Oliver Rau; Jark Boettcher; Yvonne Syha; Manfred Schubert-Zsilave 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 21 KB 👁 1 views

Additivity of Molecular Fields: CoMFA St

Additivity of Molecular Fields: CoMFA Study on Dual Activators of PPARα and PPARγ

✍ Khanna, Smriti; Sobhia, M. E.; Bharatam, Prasad V. 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 466 KB

Modulation of PPAR subtype selectivity.

Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modification

✍ Pandurang Zaware; Shailesh R. Shah; Harikishore Pingali; Pankaj Makadia; Baban T 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 923 KB

Pyridine-2-propanoic Acids: Discovery of

Pyridine-2-propanoic Acids: Discovery of Dual PPARα/γ Agonists as Antidiabetic Agents.

✍ Paul S. Humphries; Jonathon V. Almaden; Sandra J. Barnum; Thomas J. Carlson; Quy 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 15 KB 👁 1 views

Differential modulation of cell cycle, a

Differential modulation of cell cycle, apoptosis and PPARγ2 gene expression by PPARγ agonists ciglitazone and 9-hydroxyoctadecadienoic acid in monocytic cells

✍ Jade K.A. Hampel; Leon M. Brownrigg; Dayalan Vignarajah; Kevin D. Croft; Arun M. 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 290 KB

ChemInform Abstract: Modulation of PPAR

ChemInform Abstract: Modulation of PPAR Subtype Selectivity. Part 2. Transforming PPARα/γ Dual Agonist into α Selective PPAR Agonist Through Bioisosteric Modification.

✍ Rajesh Bahekar; et al. et al. 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views

Bioisosteric replacement of the rigid oxazole ring of a previously reported PPARα/γ dual agonist with a flexible lipophilic tail leads to a series of oxime containing benzyl dioxanecarboxylic acid derivatives. Compounds (I) show high selectivity towards PPARα over PPARγ in vitro. Furthermore, the hi