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SAR of α7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore

✍ Scribed by Michael R. Schrimpf; Kevin B. Sippy; Clark A. Briggs; David J. Anderson; Tao Li; Jianguo Ji; Jennifer M. Frost; Carol S. Surowy; William H. Bunnelle; Murali Gopalakrishnan; Michael D. Meyer


Book ID
113496559
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
837 KB
Volume
22
Category
Article
ISSN
0960-894X

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✍ Daniel P. Walker; Brad A. Acker; E. Jon Jacobsen; Donn G. Wishka 📂 Article 📅 2008 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 837 KB

## Abstract magnified image Three new azabicyclic amines, namely __exo__‐3‐amino‐1‐azabicyclo[3.2.1]octane, 3‐amino‐1‐azabicyclo‐[3.2.2]nonane and __exo__‐6‐amino‐8‐azabicyclo[3.2.1]octane, have been designed and prepared as isosteres of 3‐aminoquinuclidine. Aryl amides derived from each series we