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SAR Analysis of Adenosine Diphosphate (Hydroxymethyl)pyrrolidinediol Inhibition of Poly(ADP-ribose) Glycohydrolase

โœ Scribed by Koh, David W.; Coyle, Donna L.; Mehta, Nimish; Ramsinghani, Sushma; Kim, Hyuntae; Slama, James T.; Jacobson, Myron K.


Book ID
111902339
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
290 KB
Volume
46
Category
Article
ISSN
0022-2623

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A new method for the assay of poly(adeno
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## Poly(adenosine diphosphate ribulose) [poly(ADP-Rib)] glycohydrolase activity was determined by measuring the amount of ADP-Rib hydrolyzed from polymers of ADP-Rib as substrate. In principle, the method consists of incubating oligomers or polymers of [W]ADP-Rib with testis glycohydrolase. The re