Saponins from the leaves of Musanga cecropioïdes (cecropiaceae) constitute a possible source of potent hypotensive principles
✍ Scribed by A. B. Dongmo; A. Kamanyi; M. Bopelet
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 354 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The aqueous leaf extract and saponins extracted from the aqueous leaf extract of Musungu cecropioiies exhibited potent hypotensive effects in both normotensive and hypertensive rats.
The intravenous administration (direct invasive blood pressure study technique) of 1 S 3 0 m&g body weight of the aqueous leaf extract produced a fall in blood pressure (BP) of 35%-57% in hypertensive rats and 27% in normotensive individuals. This BP fall was followed by a transient rise, while saponins extracted from the aqueous extract of the leaves of MC produced a fall in BP of 55% in hypertensive and 30% in normotensive rats.
In the indirect (tail cuff) blood pressure study, the effect was also dose-dependent. The oral administration of 300 m&g body weight of the aqueous leaf extract produced a BP fall of over 30% by 12 h following extract administration while the saponins (0.Oz-O.S mgkg body weight) produced a fall of 10% to 53%.