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Sample size determination in clinical trials with time-dependent rates of losses and noncompliance

✍ Scribed by Edward Lakatos

Book ID
119143301
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
599 KB
Volume
7
Category
Article
ISSN
0197-2456

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## Abstract In a randomized clinical trial (RCT), noncompliance with an assigned treatment can occur due to serious side effects, while missing outcomes on patients may happen due to patients' withdrawal or loss to follow up. To avoid the possible loss of power to detect a given risk difference (RD