Sample size determination for the two one-sided tests procedure in bioequivalence
β Scribed by Jen-pei Liu; Shein-Chung Chow
- Book ID
- 111953198
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 156 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1573-8744
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In epidemiological prospective cohort studies, exposure levels of cases with disease and disease-free control subjects can be measured by laboratory analysis of previously stored biological specimens. In such studies, a sequential t-test can be used for preliminary evaluations, at the expense of the
## Abstract For testing average bioequivalence, a simple test that improves upon the twoβone sided test (TOST) is derived. The new test uses a critical value that is a nonβincreasing continuous function of the sample standard deviation, and the function is numerically obtained. Simulation results s