Object Γ Cohort studies in pharmacoepidemiology can result in a unique type of study, where subjects have complex types of exposure to drugs (with periods of non-exposure as well). The object of this paper is to explain how to calculate the sample size of such a study. Method Γ It is assumed that a
Sample size and optimal designs for reliability studies
β Scribed by S. D. Walter; M. Eliasziw; A. Donner
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 194 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0277-6715
No coin nor oath required. For personal study only.
β¦ Synopsis
A method is developed to calculate the required number of subjects k in a reliability study, where reliability is measured using the intraclass correlation . The method is based on a functional approximation to earlier exact results. The approximation is shown to have excellent agreement with the exact results and one can use it easily without intensive numerical computation. Optimal design configurations are also discussed; for reliability values of about 40 per cent or higher, use of two or three observations per subject will minimize the total number of observations required.
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