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Sample preparation and in situ hybridization techniques for automated molecular cytogenetic analysis of white blood cells

✍ Scribed by Frans M. van de Rijke; Hans Vrolijk; Willem Sloos; Hans J. Tanke; Anton K. Raap


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
685 KB
Volume
24
Category
Article
ISSN
0196-4763

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The immortalized, nontumorigenic human breast epithelial cell line HMT-3522 has been used as a model for premalignant and, eventually, malignant development. During cultivation, the karyotype evolution was followed. At an early stage, a very long constant phase showed a near-diploid karyotype, with