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Salvage surgery after concomitant chemoradiation in head and neck squamous cell carcinomas—Stratification for postsalvage survival

✍ Scribed by Hiang Khoon Tan; Roland Giger; Anne Auperin; Jean Bourhis; François Janot; Stephane Temam

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
170 KB
Volume
32
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

Salvage surgery after concomitant chemoradiation therapy (CCRT) for patients with head and neck squamous cell carcinomas (HNSCC) is challenging because of its associated morbidity/mortality and the poor prognoses of these patients.

Methods.

The outcome analysis of prospectively collected data from 93 patients with HNSCC with local and/or regional shows treatment failures but without distant metastasis after CCRT.

Results.

Thirty‐eight patients underwent salvage surgery, whereas 55 underwent palliative treatment, with 2‐year overall survival rates of 43.4% and 0%, respectively. Initial stage IV tumors (p = .017) and concurrent local and regional failures (p = .003) were independent predictors for decreased survival after salvage surgery. Two‐year overall survival rates for patients with 2, 1, or none of these predictive factors were 0%, 49%, and 83%, respectively (p = .0005).

Conclusion.

Salvage surgery after CCRT has acceptable outcomes. Initial stage IV tumors and concurrent local and regional failures were independent predictors that can stratify patients into distinct prognostic groups for postsalvage survival. © 2009 Wiley Periodicals, Inc. Head Neck, 2010

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