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Safety, tolerability, pharmacokinetics and pharmacodynamics of an anti- oncostatin M monoclonal antibody in rheumatoid arthritis: results from phase II randomized, placebo-controlled trials

✍ Scribed by Ernest H Choy,Marina Bendit,Dana McAleer,Feng Liu…


Book ID
126382339
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
362 KB
Volume
15
Category
Article
ISSN
1478-6354

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## Abstract ## Objective To assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of the CC chemokine receptor CCR1 antagonist MLN3897 in patients with rheumatoid arthritis (RA) receiving methotrexate (MTX). ## Methods In this phase IIa, proof‐of‐concept study, patients meeting the