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Safety, Tolerability and Pharmacokinetics of CTP-499 in a Multi-Center, Double-Blind, Two-Arm, Placebo-Controlled, Randomized Study in Non-Dialysis Patients With Stage 3 Chronic Kidney Disease


Book ID
114470907
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
211 KB
Volume
59
Category
Article
ISSN
0272-6386

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Background. Metrifonate is a long-lasting acetylcholinesterase inhibitor being developed for the symptomatic treatment of Alzheimer's disease (AD). Objectives. This study compared the ecacy, tolerability and safety of two doses of metrifonate in patients with mild-to-moderate AD, over a 26-week tre